I finished my master degree at DTU in
august 2005 as a graduate engineer at the Center for Biological
Sequence Analysis (CBS).
The topic of my master thesis was analysis and prediction of
glycation of amino acid side chains of lysines in mammalian
proteins. Glycation is a non-enzymatic process in which proteins
react with reducing sugar molecules. The sugar molecules thereby
impair the function and change the characteristics of the proteins.
I used artificial neural networks (ANNs) to predict glycation sites
in these proteins. ANNs are a computer based form of artificial
intelligence.
I have also worked with enzymatic acetylation of the amino side
chains of lysines in eukaryotic proteins. Acetylation is a
regulatory mechanism in cells.
Currently I am using ANNs to predict if a genomic variation in the
form of a non-synonymous single-nucleotide polymorphism (nsSNP)
causes a disease. I am also involved in a project where the aim is
to prioritize genomic variations with respect to the likelihood of
being causative of a specific change in phenotypic characteristics.
An example of such a phenotypic change could be increased or
decreased activity of a protein.