Professor Lone Gram studies bacterial eco-physiology and biotechnology. The science is focused on aquatic bacteria (freshwater and marine) and covers both pathogeneic bacteria as well as beneficial bacteria. The purpose of our research is to control bacteria that cause disease in man or fish. Our studies are aimed at understanding how we can influence virulence and behaviour in pathogenic bacteria and also we study novel principles and compounds that can control pathogenic bacteria. Lone and her group are course responsible for courses at DTU and several project students are affiliated with the group. Also, the group has an extensive international network.
 

CV

Education

1980 - 1985 Food Science - The Royal Veterinary and Agricultural University, Denmark

Academic grades

Ph.D. (1989, Microbiology), M.Sc. (1985, Food Science)

Professional experience

2013 - Professor - Technical University of Denmark, Dept. of Systems Biology
1986 - 1989 PhD student - The Royal Veterinary and Agricultural University
1988 - 1993 Scientist - Technological Laboratory
1993 - 2000 Senior scientist - National Institute for Fisheries Research
2000 - 2005 Research Council Professor - National Institute for Fisheries Research
2005 - 2010 Research Professor - Technical University of Denmark, Danish Institute for Fisheries Research
2011 - Professor - Techncial University of Denmark, National Food Institute

Languages

Danish (mother tongue), English (fluent)

Expertise

My group studies the ecology and physiology of aquatic microorganisms. This includes studies of bacteria such as Roseobacter, Pseudoalteromonas, Vibrio, Shewanella, fluorescent pseudomonads or Listeria monocytogenes. Part of the work deals with pathogenic bacteria and food safety and infection (Gram 2005, Gram and Huss 2000) and part of the work with the biotechnological potential of marine bacteria (Gram et al. 2010). We work on control on unwanted bacteria (pathogens and spoilage bacteria) and work with both live fish and seafood products. Also, we have a more general interst in the development of novel antibacterial compounds (such as small organic molecules, antimicrobial peptides, enzymes) that may be used in clinical settings or as antifouling agents. Our work with L. monocytogenes focuses on seafood safety and we study environmental niches, spread, colonization, inhibition and virulence of the bacterium. We are interested in aquacultured fish species; in particular non-antibiotic based disease control methods such as probiotics or blocking of bacteria quorum sensing. Potential fish probiotics include Roseobacter and Pseudomonas species. Methods range from traditional culturing, phenotypic characterization to typing by RAPD and antibody and probe detection. Several of our current research projects deal with various aspects of interactions between bacteria and between bacteria and the eucaryotic host . We use the understanding of bacteria-bacteria-interactions (especially antagonism) to search for novel antibacterial compounds. In 2006, we have joined a global scientific marin cruise (Galathea3) where we will determine the distribution of bacteria with antibacterial activity in the marine environment around the globe. This work can potentially be of interest in development of novel food preservation compounds, antifouling agents and even in drug discovery work.

International experience

2009: Research visit to Harvard Medical School (4 months) 1999: Research visit to University of New South Wales (1½ month) 1995: Research visit to University of New South Wales (7 months) 2006-to date: Adjunct Professor at University of Maryland 1998-2009 Member and 2003-2007 secretary of ICMSF; the International Commission on Microbiological Specifications for Foods 1986-1993: Several consultancies for the Food and Agricultural Organization of the United Nations working on projects and courses in Africa related to fish technology

Other information

2008: Awarded Kaufmann's Mindefond and Tagea Brandt's travel award 2007-to date: Editor of Applied and Environmental Microbiology.2006-2012. Member of the Danish Council for Research Policy 2008-2011. Member since 2013 of the Danish Research Council for Natural Sciences.

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Publications

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