Erik Huusfeldt Larsen

Erik Huusfeldt Larsen

Senior Researcher, group manager

Mørkhøj Bygade 19, Building B, Room 227

2860 Søborg

Denmark

Phone: 35887631

Fax: 35887448

My field of research is toxic and essential trace elements and their metabolites in food, in relation to health and disease. The chemical analysis of trace elements and their species in food and human samples has been studied using coupled techniques, including HPLC-mass spectrometry. Recently, detection of nanoparticles in biological samples has been studied by field flow fractionation with detection by light scattering and mass spectrometry.

Food monitoring data and estimation of intake of toxic or essential trace elements from constitute a valuable point of reference for evaluation of food safety, partially due to the impact of environmental contamination by heavy metals.

Human research projects include identification of biomarkers of intake of selenium in samples from intervention trials and application of isotope-specific analyses for estimation of bioavailability.

The essential minerals are micronutrients that prevent deficiency diseases. The possible sub-optimum intake of an essential mineral via the diet is the primary criterion for initiation of research activities on e.g. selenium and iodine. The research aims to clarify which molecular forms (species) of minerals that occurs in food and to differentiate their biological effects. Detailed knowledge of occurring molecular forms of a mineral is necessary for evaluation of its nutritional value.

Finally, biological monitoring of toxic and essential trace elements in blood, urine and faeces may provide additional information on the nutritional impact, fate and excretion from the human body. Such measurements are often conducted by chromatographic separation techniques coupled with inductively coupled plasma mass spectrometry (ICP-MS).

CV

Education

- 1976 M.Sc. degree - The Royal Danish School of Pharmacy
- 1993 Ph.D - The Royal Danish School of Pharmacy

Academic grades

Cand. pharm

Ph.D

Professional experience

1977 - Associate professor (temporary position) - The Royal Danish School of Pharmacy, Institute of Analytical and General Chemistry
1989 - Analytical chemist - The Danish Veterinary and Food Administration
- 1993 Ph.D - The Royal Danish School of Pharmacy
1993 - Senior Research Chemist - The Danish Veterinary and Food Administration, Institute of Food Chemistry and Nutrition
2004 - Research professor - Danish Institute for Food and Veterinary Research

Expertise

My field of research is toxic and essential trace elements and their metabolites in food, in relation to health and disease. The chemical analysis of trace elements and their species in food and human samples has been studied using coupled techniques, including HPLC-mass spectrometry. Recently, detection of nanoparticles in biological samples has been studied by field flow fractionation with detection by light scattering and mass spectrometry.

Food monitoring data and estimation of intake of toxic or essential trace elements from constitute a valuable point of reference for evaluation of food safety, partially due to the impact of environmental contamination by heavy metals.

Human research projects include identification of biomarkers of intake of selenium in samples from intervention trials and application of isotope-specific analyses for estimation of bioavailability.

The essential minerals are micronutrients that prevent deficiency diseases. The possible sub-optimum intake of an essential mineral via the diet is the primary criterion for initiation of research activities on e.g. selenium and iodine. The research aims to clarify which molecular forms (species) of minerals that occurs in food and to differentiate their biological effects. Detailed knowledge of occurring molecular forms of a mineral is necessary for evaluation of its nutritional value.

Finally, biological monitoring of toxic and essential trace elements in blood, urine and faeces may provide additional information on the nutritional impact, fate and excretion from the human body. Such measurements are often conducted by chromatographic separation techniques coupled with inductively coupled plasma mass spectrometry (ICP-MS).

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