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Organisation profile

Background:

Biologists, chemists and physicists lack tools to observe the ubiquitous processes in liquids with nanoscale resolution. Our work aims at developing novel tools based on micro and nanofabricated devices for high resolution imaging with light and electron microscopes to provide new insights into biological, physical and chemical processes.

Projects: 

  • In-situ TEM of nanoelectronics: We are working on methods that allow us to follow the creation of nanodevices in-situ TEM by nanowire growth, and also the processes taking place in nanodevices with nanowires during use. See FTP Project “Nano-Live” on Imaging Nanoelectronics Live by Transmission Electron Microscopy. Danish Research Counsil for Technology and Production Case No. 10-082797

  • Imaging nanoparticles in food: EU project FP7-Nanolyse - Nanoparticles in Food: Analytical methods for detection and characterisation.
  • Creation of nanotube electrodes of cellular measurements and characterization of the cell-nanotube interface. EU project FP7-Technotubes (Technology for Wafer-Scale Carbon Nanotube Applications) (2009-2012) - Grant agreement no.: CP-IP 228579-1.
  • Environmental electron microscopy methods have been developed for mainly studying gas phase reactions, but live imaging of processes in the liquid phase is lagging behind. We are developing microfluidic system with thin membrane windows that are transparent to the electron beam in SEM and TEM. Combining these windows with the diverse functionality of microfluidic chip systems makes it possible to obtain electron microscopic images with nanoscale resolution in liquids to study numerous processes under controlled conditions, such as biological, chemical and electrochemical processes.

    DTU PhD project with DTU Center for Electron Nanoscopy (2009-2012), "Electron Microscopy of Liquid Processes".  

A number of our activities are based on exploring interactions between cells and nanostructures. We are developing focused ion beam milling combined with scanning electron microscopy to provide 3D images of cells based on standard and cryogenic fixation methods. We are also studying how cells move on nanostructured surfaces and how the surface chemistry and geometry influences the cell motility and developing time lapse microscopy techniques for this. 

In addition we are working on developing a number of novel imaging and in-situ manipulation and control methods for electron microscopy together with the Center for Electron Nanoscopy (CEN) at DTU.

 

Contact information

Ørsteds Plads
345 Ø
DK-2800
Kgs. Lyngby
Denmark
  • Phone: (+45) 4525 5700
  • Fax: (+45) 4588 7762
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  • Microscopy and Microanalysis

    ISSNs: 1431-9276

    ISSNs (Electronic): 1435-8115

    Cambridge University Press, United Kingdom

    ISI indexed (2013): yes, FI (2013): 1

    Central database

    Journal

  • Analytical and Bioanalytical Chemistry

    ISSNs: 1618-2642, 16182642

    ISSNs (Electronic): 0939-006

    Springer, Germany

    ISI indexed (2013): yes, FI (2013): 1

    Central database

    Journal

  • Nanoscale

    ISSNs: 2040-3364, 20403364

    ISSNs (Electronic): 2040-3372

    royal society of chemistry, United Kingdom

    ISI indexed (2013): yes, FI (2013): 2

    Central database

    Journal

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