Department of Systems Biology

  1. 2015
  2. E-pub ahead of print

    Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways.. / Ninel Hansen, Stine; Westergaard, David ; Borg Houlberg Thomsen, Mathilde; Vistesen, Mette; Nguyen Do, Khoa; Fogh, Louise; Belling, Kirstine C.; Wang, Jun; Yang, Huanming; Gupta, Ramneek; Ditzel, Henrik Jørn; Moreira, José ; Brünner, Nils; Stenvang, Jan; Schrohl, Anne-Sofie.

    In: Tumor Biology, 2015.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  3. Published

    Airway Mucosal Immune-suppression in Neonates of Mothers Receiving A(H1N1)pnd09 Vaccination During Pregnancy. / Pedersen, Susanne Brix; Bischoff, Anne L.; Folsgaard, Nilofar V.; Vissing, Nadja H.; Birch, Sune; Bisgaard, Hans .

    In: Pediatric Infectious Disease Journal, Vol. 34, No. 1, 2015, p. 84-90.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  4. Published

    Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation. / Fan, Yuzhou; Jimenez Del Val, Ioscani; Müller, Christian; Wagtberg Sen, Jette; Rasmussen, Søren Kofoed; Kontoravdi, Cleo; Weilguny, Dietmar; Andersen, Mikael Rørdam.

    In: Biotechnology and Bioengineering, Vol. 112, No. 3, 2015, p. 521-535.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  5. Published

    A novel common variant in DCST2 is associated with length in early life and height in adulthood. / van der Valk, Ralf J.P.; Kreiner-Møller, Eskil; Kooijman, Marjolein N.; Guxens, Mònica; Stergiakouli, Evangelia; Sääf, Annika; Bradfield, Jonathan P.; Geller, Frank; Hayes, M. Geoffrey; Cousminer, Diana L.; Bisgaard, Hans; Chawes, Bo; Stokholm, Jakob; Waage, Johannes; Eriksen, Patrick; Sevelsted, Astrid; Melbye, Mads; Feenstra, Bjarke; Pers, Tune Hannes; Bønnelykke, Klaus.

    In: Human Molecular Genetics, Vol. 24, No. 4, 2015, p. 1155-1168.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  6. Published

    Archival Bone Marrow Samples: Suitable for Multiple Biomarker Analysis?. / Lund, Bendik; Najmi, A. Laeya; Wesolowska, Agata; Landsem, Veslemoy M.; Rasmussen, Kirsten K.; Borst, Louise; Gupta, Ramneek; Schmiegelow, Kjeld; Klungland, Helge.

    In: Applied Immunohistochemistry & Molecular Morphology, Vol. 23, No. 1, 2015, p. 71-77.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  7. Published
  8. Published

    Bioinformatics prediction of swine MHC class I epitopes from Porcine Reproductive and Respiratory Syndrome Virus. / Welner, Simon; Nielsen, Morten; Lund, Ole; Jungersen, Gregers; Larsen, Lars Erik.

    2015. Abstract from Keystone Symposia on Molecular and Cellular Biology: Accelerating life science discovery, Keystone, United States.

    Publication: Research - peer-reviewConference abstract for conference – Annual report year: 2015

  9. Published

    Characterization of Alternaria strains from Argentinean blueberry, tomato, walnut and wheat. / Andersen, Birgitte; Nielsen, Kristian Fog; Fernández Pinto, Virginia; Patriarca, Andrea.

    In: International Journal of Food Microbiology, Vol. 196, 2015, p. 1-10.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  10. Published
  11. Published
  12. Published

    CTX-M-1 β-lactamase expression in Escherichia coli is dependent on cefotaxime concentration, growth phase and gene location.. / Kjeldsen, Thea S. B.; Overgaard, Martin; Nielsen, Søren S.; Bortolaia, Valeria; Jelsbak, Lotte; Sommer, Morten Otto Alexander; Guardabassi, Luca; Olsen, John E.

    In: Journal of Antimicrobial Chemotherapy, Vol. 70, No. 1, 2015, p. 62-70.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  13. In press

    Dereplication-guided isolation of depsides thielavins S–T and lecanorins D–F from the endophytic fungus Setophoma sp.. / Soman De Medeiros, Lívia; Abreu, Lucas M.; Nielsen, Anita; Ingmer, Hanne; Larsen, Thomas Ostenfeld; Nielsen, Kristian Fog; Rodrigues-Filho, Edson.

    In: Phytochemistry, 2015.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  14. Published

    Dynamic single-cell analysis of Saccharomyces cerevisiae under process perturbation: Comparison of different methods for monitoring the intensity of population heterogeneity. / Delvigne, Frank; Baert, Jonathan; Gofflot, Sébastien; Lejeune, Annick; Telek, Samuel; Johanson, Ted; Eliasson Lantz, Anna.

    In: Journal of Chemical Technology and Biotechnology, Vol. 90, No. 2, 2015, p. 314–323.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  15. Published
  16. Published

    Genomic Dissection of Travel-Associated Extended-Spectrum-Beta-Lactamase-Producing Salmonella enterica Serovar Typhi Isolates Originating from the Philippines: a One-Off Occurrence or a Threat to Effective Treatment of Typhoid Fever?. / Hendriksen, Rene S.; Leekitcharoenphon, Pimlapas; Mikoleit, Matthew; Jensen, Jacob Dyring; Kaas, Rolf Sommer; Roer, Louise; Joshi, Heena B.; Pornruangmong, Srirat; Pulsrikarn, Chaiwat; Gonzalez-Aviles, Gladys D.; Reuland, E. Ascelijn; Al Naiemi, Nashwan; Wester, Astrid Louise; Aarestrup, Frank Møller; Hasman, Henrik.

    In: Journal of Clinical Microbiology, Vol. 53, No. 2, 2015, p. 20677-680.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  17. Published

    Genomic Signature of Multidrug-Resistant Salmonella enterica Serovar Typhi Isolates Related to a Massive Outbreak in Zambia between 2010 and 2012.. / Hendriksen, Rene S.; Leekitcharoenphon, Pimlapas; Lukjancenko, Oksana; Lukwesa-Musyani, Chileshe; Tambatamba, Bushimbwa; Mwaba, John; Kalonda, Annie; Nakazwe, Ruth; Kwenda, Geoffrey; Jensen, Jacob Dyring; Svendsen, Christina Aaby; Dittmann, Karen K.; Kaas, Rolf Sommer; Cavaco, Lina; Aarestrup, Frank Møller; Hasman, Henrik; Mwansa, James C. L.

    In: Journal of Clinical Microbiology, Vol. 53, No. 1, 2015, p. 262-272.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  18. Published

    Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection. / Esaki, Hitokazu; Ewald, David Adrian; Ungar, Benjamin; Rozenblit, Mariya; Zheng, Xiuzhong; Xu, Hui; Estrada, Yeriel D.; Peng, Xiangyu; Mitsui, Hiroshi; Litman, Thomas; Suarez-Farinas, Mayte; Krueger, James G.; Guttman-Yassky, Emma.

    In: Journal of Allergy and Clinical Immunology, Vol. 135, No. 1, 2015, p. 153-163.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  19. Published
  20. E-pub ahead of print
  21. Published
  22. Published

    Metagenomic heterogeneity explains dual immune effects of endotoxins. / Pedersen, Susanne Brix; Eriksen, Carsten; Larsen, Jeppe Madura; Bisgaard, Hans Flinker.

    In: Journal of Allergy and Clinical Immunology, Vol. 135, No. 1, 2015, p. 277-280.

    Publication: Research - peer-reviewComment/debate – Annual report year: 2015

  23. Published

    Microbial Biofilm as a Smart Material. / Garde, Christian; Welch, Martin; Ferkinghoff-Borg, Jesper; Sams, Thomas.

    In: Sensors, Vol. 15, No. 2, 2015, p. 4229-4241.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  24. Published

    Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios. / Besenbacher, Søren; Liu, Siyang; Gonzalez-Izarzugaza, Jose Maria; Grove, Jakob; Belling, Kirstine C.; Bork-Jensen, Jette; Huang, Shujia; Dam-Als, Thomas; Li, Shengting; Yadav, Rachita; Yadav, Rachita; Rubio García, Arcadio; Lescai, Francesco; Demontis, Ditte ; Rao, Junhua ; Ye, Weijian ; Mailund, Thomas; Friborg, Rune M. ; Pedersen, Christian N. S.; Xu, Ruiqi; Sun, Jihua; Liu, Hao ; Wang, Ou ; Cheng, Xiaofang ; Flores Santa Cruz, David; Rydza, Emil Karol; Rapacki, Kristoffer; Sørensen, John Damm; Chmura, Piotr Jaroslaw; Westergaard, David; Dworzynski, Piotr; Sørensen, Thorkild I. A.; Lund, Ole; Hansen, Torben; Xu, Xun; Li, Ning; Bolund, Lars; Pedersen, Oluf; Eiberg, Hans; Krogh, Anders; Børglum, Anders D.; Brunak, Søren; Kristiansen, Karsten; Schierup, Mikkel H; Jun, Wang; Gupta, Ramneek; Villesen, Palle ; Rasmussen, Simon.

    In: Nature Communications, Vol. 6, 5969, 2015.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  25. Published

    Optimering af vandforsyningens moniteringsstrategi ved hjælp af GIS-analyse. / Albrechtsen, Hans-Jørgen (Author); Christensen, Sarah Christine Boesgaard (Author); Grønkjær, Thomas (Author); Kirstein, Jonas (Author); Larsen, Sille Lyster (Author); Rygaard, Martin (Author).

    2015. Dansk Vand Konference 2014, Århus, Denmark, 18/11/14.

    Publication: ResearchSound/Visual production (digital) – Annual report year: 2015

  26. Published

    Physiological and proteome studies of responses to heat stress during grain filling in contrasting wheat cultivars. / Wang, Xiao; Dinler, Burcu Seckin; Vignjevic, Marija; Jacobsen, Susanne; Wollenweber, Bernd .

    In: Plant Science, Vol. 230, 2015, p. 33-50.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  27. Published

    Renal impairment and late toxicity in germ-cell cancer survivors.. / Lauritsen, J.; Mortensen, M. S.; Kier, M. G. G.; Christensen, I. J.; Agerbaek, M.; Gupta, Ramneek; Daugaard, G.

    In: Annals of Oncology, Vol. 26, No. 1, 2015, p. 173-178.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  28. Published
  29. Published

    SNPsnap: a Web-based tool for identification and annotation of matched SNPs. / Pers, Tune Hannes; Timshel, Pascal; Hirschhorn, Joel N.

    In: Bioinformatics, Vol. 31, No. 3, 2015, p. 418-420.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  30. Published

    Spatio-temporal appearance of α-amylase and limit dextrinase in barley aleurone layer in response to gibberellic acid, abscisic acid and salicylic acid.. / Shahpiri, Azar; Talaei, Nasim; Finnie, Christine.

    In: Journal of the Science of Food and Agriculture, Vol. 95, No. 1, 2015, p. 141-147.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  31. Published

    Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria. / Lau, Clinton K.Y.; Turner, Louise; Jespersen, Jakob S.; Lowe, Edward D. ; Petersen, Bent; Wang, Christian W.; Petersen, Jens E.V.; Lusingu, John; Theander, Thor G.; Lavstsen, Thomas; Higgins, Matthew K.

    In: Cell Host & Microbe, Vol. 17, 2015, p. 118-129.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  32. Published

    Tabhu: tools for antibody humanization.. / Olimpieri, Pier Paolo; Marcatili, Paolo; Tramontano, Anna.

    In: Bioinformatics, Vol. 31, No. 3, 2015, p. 20434-20435.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  33. E-pub ahead of print

    Traces of ATCV-1 associated with laboratory component contamination. / Kjartansdóttir, Kristín Rós ; Friis-Nielsen, Jens; Asplund, Maria ; Mollerup, Sarah ; Mourier, Tobias ; Holm Jensen, Randi ; Arn Hansen, Thomas; Rey-Iglesia, Alba ; Raith Richter, Stine ; Alquezar-Planas, David E. ; Olsen, Pernille V. S. ; Vinner, Lasse ; Fridholm, Helena ; Sicheritz-Pontén, Thomas; Nielsen, Lars Peter; Brunak, Søren; Willerslev, Eske; Gonzalez-Izarzugaza, Jose Maria; Hansen, Anders Johannes .

    In: National Academy of Sciences. Proceedings, 2015.

    Publication: Research - peer-reviewLetter – Annual report year: 2015

  34. Published
  35. Published

    Urea and thiourea modified polypropyleneimine dendrimers clear intracellular α-synuclein aggregates in a human cell line. / Laumann, Kristoffer; Boas, Ulrik; Larsen, Hjalte Martin; Heegaard, Peter M. H.; Bergström, Ann-Louise.

    In: Biomacromolecules, Vol. 16, No. 1, 2015, p. 116-124.

    Publication: Research - peer-reviewJournal article – Annual report year: 2015

  36. Published

    Whey-reduced weight gain is associated with a temporary growth reduction in young mice fed a high-fat diet. / Tranberg, Britt; Madsen, Andreas N.; Hansen, Axel K.; Hellgren, Lars.

    In: Journal of Nutritional Biochemistry, Vol. 26, No. 1, 2015, p. 9–15.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  37. 2014
  38. Published
  39. Published
  40. Published
  41. Published

    Acute and perinatal-programming effects of a fat-rich diet on rat muscle mitochondrial function and hepatic lipid accumulation.. / Hellgren, Lars; Jensen, Runa I.; Waterstradt, Michelle S. G. ; Quistorff, Bjørn; Lauritzen, Lotte.

    In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 93, 2014, p. 1170-1180.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  42. Published

    Adipose tissue trans fatty acids and changes in body weight and waist circumference. / Hansen, Camilla P.; Berentzen, Tina L.; Østergaard, Jane N.; Dahm, Christina C.; Hellgren, Lars; Schmidt, Erik B.; Tjønneland, Anne; Sørensen, Thorkild I. A.; Overvad, Kim; Jakobsen, Marianne U.

    In: The British Journal of Nutrition, Vol. 111, No. 7, 2014, p. 1283-1291.

    Publication: Research - peer-reviewJournal article – Annual report year: 2013

  43. Published

    A DNA-binding-site landscape and regulatory network analysis for NAC transcription factors in Arabidopsis thaliana.. / Lindemose, Søren; Jensen, Michael Krogh; de Velde, Jan Van; O'Shea, Charlotte; Heyndrickx, Ken S.; Workman, Christopher; Vandepoele, Klaas; Skriver, Karen; De Masi, Federico.

    In: Nucleic Acids Research, Vol. 42, No. 12, 2014, p. 7681-7693.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  44. Published

    Adsorption and nanowear properties of bovine submaxillary mucin films on solid surfaces: Influence of solution pH and substrate hydrophobicity. / Sotres, Javier; Madsen, Jan Busk; Arnebrant, Thomas; Lee, Seunghwan.

    In: Journal of Colloid and Interface Science, Vol. 428, 2014, p. 242-250.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  45. Published

    Ageing of atrazine in manure amended soils assessed by bioavailability to Pseudomonas sp. strain ADP. / Glæsner, Nadia; Bælum, Jacob; Strobel, Bjarne W.; Jacobsen, Carsten S.

    In: Biodegradation, Vol. 25, No. 2, 2014, p. 217-225.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  46. Published

    A Generally Applicable Translational Strategy Identifies S100A4 as a Candidate Gene in Allergy. / Bruhn, Sören; Fang, Yu; Barrenäs, Fredrik; Gustafsson, Mika; Zhang, Huan; Konstantinell, Aelita; Krönke, Andrea; Sönnichsen, Birte; Bresnick, Anne; Dulyaninova, Natalya; Wang, Hui; Zhao, Yelin; Klingelhöfer, Jörg; Ambartsumian, Noona; Beck, Mette Kristina; Nestor, Colm; Bona, Elsa; Xiang, Zou; Benson, Mikael.

    In: Science Translational Medicine, Vol. 6, No. 218, 2014, p. 20218ra4-218ra4.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  47. Published

    A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.. / Bønnelykke, Klaus; Sleiman, Patrick; Nielsen, Kasper; Kreiner-Møller, Eskil; Mercader, Josep M; Belgrave, Danielle; den Dekker, Herman T; Husby, Anders; Sevelsted, Astrid; Faura-Tellez, Grissel; Mortensen, Li Juel; Paternoster, Lavinia; Flaaten, Richard; Mølgaard, Anne; Smart, David E; Thomsen, Philip Francis; Rasmussen, Morten; Bonàs-Guarch, Silvia; Holst, Claus; Nohr, Ellen A; Yadav, Rachita; March, Michael E; Blicher, Thomas Holberg; Lackie, Peter M; Jaddoe, Vincent W V; Simpson, Angela; Holloway, John W; Duijts, Liesbeth; Custovic, Adnan; Davies, Donna E; Torrents, David; Gupta, Ramneek; Hollegaard, Mads Vilhelm; Hougaard, David M; Hakonarson, Hakon; Bisgaard, Hans Flinker.

    In: Nature Genetics, Vol. 46, 2014, p. 51-55.

    Publication: Research - peer-reviewLetter – Annual report year: 2013

  48. Published
  49. Published

    A kinetic model of thiamine biosynthesis in Escherichia coli. / Matos, Marta; Herrgard, Markus; Andersen, Mikael Rørdam; Sonnenschein, Nikolaus.

    Abstract Book - DTU Sustain Conference 2014. Kgs. Lyngby : Technical University of Denmark, 2014.

    Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2014

  50. Published

    Analysis of pan-genome content and its application in microbial identification. / Lukjancenko, Oksana; Ussery, David (Main supervisor); Larsen, Mette Voldby (Supervisor).

    Technical University of Denmark, 2014. 177 p.

    Publication: ResearchPh.D. thesis – Annual report year: 2014

  51. Published

    Analysis of surface binding sites (SBSs) in carbohydrate active enzymes with focus on glycoside hydrolase families 13 and 77 : — a mini-review. / Cockburn, Darrell; Wilkens, Casper; Ruzanski, Christian; Andersen, Susan; Willum Nielsen, Jonas; Smith, Alison M.; Field, Robert A.; Willemoes, Martin; Abou Hachem, Maher ; Svensson, Birte.

    In: Biologia, Vol. 69, No. 6, 2014, p. 705-712.

    Publication: Research - peer-reviewJournal article – Annual report year: 2014

  52. Published
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