Network Reconstruction and in-silico Biology The section reconstruct metabolic, protein synthesis, and regulatory networks for industrially-relevant microorganismsand products using bioinformatic approaches and manual curation. We develop constraint-based modeling approaches, reconstruction methods, and omics data integration approaches to understand biological phenotypes.The majority of activities in the section takes place at the Center satellite at UCSD.

We use adaptive laboratory evolution to study dynamics of bacterial adaptation, genetic causality, and microbial bioprocessing capabilities. We distribute the reconstructed networks and developed methods to the core team to drive metabolic engineering through modeling.

The section is headed by Professor Bernhard Palsson.