Bacterial Physiology and Genetics Group

Former organisational unit. 25/01/05.

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Organisation profile

The main research objects of the BPG group are the industrially important gram-positive bacteria: Bacilli and Lactic acid bacteria. These bacteria are used extensively for bulk enzyme productions and as starter cultures for food fermentations, respectively. Mainly the model organisms Bacillus subtilis and Lactococcus lactis are used in the research using methods from the fields of genetics, molecular biology, functional genomics and cell physiology. The main goal is to understand and eventually predict the performance of the bacteria in different environmental conditions; in other words, to study the interplay between a given genotype of the bacteria with changing environmental conditions. By the use of molecular genetics precise changes of specific genes are constructed and the performance of the bacterium with this new genotype is studied in a number of environmental conditions . DNA arrays and proteomics are used for studying the global regulatory networks controlling cellular energetics, carbon and nitrogen metabolism as well as various stress responses. Control Analysis is also widely used, and the group has made important contributions to the development of genetic tools for modulating steady state gene expression in various industrially important microbial systems. Main topics of specific interests are: Nucleotide metabolism, energy metabolism, stress response and bacteriophages.
 

Contact information

Søltofts Plads
221
DK-2800
Kgs. Lyngby
Denmark
  • Phone: +45 45 25 26 00
  • Fax: +45 45 88 49 22
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ID: 1988